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Oklys - Painkiller Without Analogue in Bulgaria from BestaMed

Pain is never welcome! Ask for Oklys!

02 Feb 2021
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Oklys - Painkiller Without Analogue in Bulgaria from BestaMed

Unique for the Bulgarian medicinal products market, Oklys® is the newest brand of BestaMed. Oklys® successfully helps in the fight against pain due to the formula, ibuprofen L-arginine.

The innovative composition of Oklys® makes it the only one of its kind in Bulgaria, a painkiller that relieves immediately and guarantees a quick and lasting analgesic effect. Oklys® has proven its effectiveness and affects pain in muscle and bone diseases and inflammation, headache, toothache, postoperative pain, primary dysmenorrhea, rheumatoid arthritis and juvenile rheumatoid arthritis, ankylosing spondylitis, osteoarthritis and other acute or chronic rheumatic processes. Anesthetizes soft tissues in sprains and strains, has a beneficial effect on pharyngitis, tonsillitis, ear infections.

The innovation in Oklys

OKLYS / OKLYS FORTE is the only one of its kind ibuprofen L-arginine in Bulgaria.

Searching a way to further accelerate the analgesic effect of ibuprofen at the end of the 20th century, the combination of ibuprofen and L-arginine was found that provides much faster absorption of the active substance. Ibuprofen L - arginine has 2 to 5 times faster absorption compared to products containing racemic ibuprofen, t max is 20 minutes after administration on an empty stomach (SPC). 

t max - the time for which the peak (highest) concentration in the blood is reached.

Faster absorption leads to faster pain relief with the same side effect profile. A 2017 trial* in healthy volunteers measured changes in PGE2 (prostaglandin E2 - the enzyme responsible for the onset of pain) levels  compared to pre-administration levels of different pharmaceutical forms of ibuprofen and found significant differences.

Although the different forms reach similar levels of enzyme inhibition, the pharmaceutical form ibuprofen L-arginine significantly increases the weighted average inhibition of PGE2 compared to standard ibuprofen in the eight-hour period post oral administration.

The innovative formula of Oklys and Oklys Forte - ibuprofen L-arginine allows the active substance to penetrate as quickly as possible into the body and counteract the mechanisms leading to the manifestation of pain.

Both products - Oklys 400 mg and Oklys Forte 600 mg allow precise adherence to the principle of the lowest effective dose, both in a single dose and within a twenty-four hour period.

Oklys and Oklys Forte are available in the pharmacies throughout the country.

Learn more at https://www.oklys.bg/

 * Shin D. et al. Pharmacokinetic and pharmacodynamic evaluation according to absorption differences in three formulations of ibuprofen. Drug Design, Development and Therapy 2017: 11 135-141